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Ryan B. Dienst
Ryan B. Dienst

Finding the signal
in the noise.

Commercial Strategy·Business Transformation·Data-Driven Growth

I build, scale, and transform businesses by finding what actually drives performance and getting everyone aligned around it. Twenty-five years as a founder, CEO, and Chief Commercial Officer, with two successful exits.

About

The answer is almost always in the data. The problem is almost always that no one is looking at the right data together.

I co-founded Global Medical Imaging and grew it to $30M before its sale to private equity. I then founded Highline Labs and grew it from zero to $24M before its acquisition by Mako Medical. Two companies built from a standing start, and two exits.

At Mako, I helped lead the company through the COVID surge as revenue grew from $30M to approaching $1 billion, then moved into the Chief Commercial Officer role and led the restructuring that followed. Today I hold direct P&L accountability for a $60M clinical diagnostics market with oversight of another $60M, and I serve as CEO of Centennial Diagnostics.

The thread through all of it: find the signal inside complicated organizations, build the infrastructure that makes it visible, and align the team around it by teaching the why, not just the what.

Results

Measured outcomes, not adjectives.

2
Companies founded and sold ($30M and $24M)
$120M
Commercial revenue scope at Mako Medical
5,000 → 600
Organization restructured without losing the revenue base
11%
Revenue conversion gain through AI-enabled workflows
22% → <10%
Cost of sales after the commercial rebuild
28% → 20%
Phlebotomy cost, driven by shared operating data
4×
Ernst & Young Entrepreneur of the Year
3×
Inc. 5000 Fastest-Growing Companies
How I Lead

Four principles I hold myself to.

Lead with the why.

Teams that understand the reasoning make better decisions in the field and execute faster, without waiting for permission.

Collaborative before decisive.

I start with the people closest to the problem. Once the input is in, I commit and execute without ambiguity.

One version of the truth.

When everyone sees the same data, the conversation moves from debating the numbers to solving the problem.

Bad news fast.

Problems surfaced early get solved early. I hold myself to that with ownership and boards, and expect it from my team.

Defining Decisions

Three moments that shaped how I lead.

Every leader has a philosophy. These are the situations that tested mine.

Mako Medical

Restructuring with the people closest to the work

I led the restructuring of a commercial organization from more than 5,000 employees at its peak to about 600. Direction was set with ownership. The solutions came department by department, from the people who ran sales, account management, customer service, revenue cycle, and phlebotomy. Customer service went from 30 people to 9 without losing service quality.

Large-scale change needs both decisiveness and involvement.
Centennial Diagnostics

Stopping what the data said to stop

As CEO, I recommended shutting down a clinical blood testing expansion that was launched before I arrived. After months of testing pricing, go-to-market, and customer segments, the evidence was clear: the losses were putting a healthy molecular business at risk. Stopping it protected the core.

Would I make this investment today, knowing what I know now?
Global Medical Imaging

Telling the board what it needed to hear

After our sale to private equity, the capital behind the planned acquisition strategy was no longer available. I went to the board with the data and a bridge strategy built on operational execution and margin. We executed it, and when capital returned, the original strategy went forward.

Boards need reality more than optimism.
Experience

Founder, CEO, and commercial executive.

2024 – Present

Chief Commercial Officer · Mako Medical

Direct P&L accountability for a $60M clinical diagnostics market and commercial oversight of a $60M senior care market. Led the commercial restructuring, rebuilt compensation, built AWS operating dashboards, and led the company's AI initiatives.

2023 – Present

Chief Executive Officer · Centennial Diagnostics

Full P&L ownership of a $12M molecular diagnostics laboratory operating independently within the Mako Medical family.

2020 – 2024

EVP, Strategy & Business Development · Mako Medical

Joined through the Highline Labs acquisition and helped lead commercial strategy and market expansion as the company scaled through the COVID surge.

2014 – 2020

Founder & CEO · Highline Labs

Built a CAP-accredited clinical laboratory from zero to $24M in annual revenue and about 50 employees. Acquired by Mako Medical.

2003 – 2011

Co-Founder & CEO · Global Medical Imaging

Grew an ultrasound distributor into a $30M medical imaging technology and services company with about 100 employees. Sold to private equity; led the business through the post-acquisition year with monthly board reporting.

Education

MBA, Kenan-Flagler Business School, University of North Carolina
BS with Honors, University of North Carolina at Chapel Hill

Recognition

Ernst & Young Entrepreneur of the Year (four times)
Inc. 5000 Fastest-Growing Companies (three times)
Entrepreneur Magazine Hot 500

How I Start

I don't walk in with answers. I walk in with a process.

The same approach I used to restructure Mako's commercial organization. Each phase informs the next, and nothing gets decided before it has been tested.

Days 1 to 30

Listen and Learn

Meet the team, the customers, and the cross-functional leaders. Inventory the data and learn what has already been tried.

Days 31 to 60

Diagnose and Shape

Set baselines, build working hypotheses, assess talent, and test the direction informally with key leaders.

Days 61 to 90

Decide and Align

Finalize the plan and targets, secure approvals, and build the why so every leader can explain it to their team.

Day 90 and Beyond

Execute and Measure

Run the plan against a shared scorecard, review it monthly, and adjust as the market answers our questions.

Let's find the signal.

Whether you're leading a growth company, a transformation, or a portfolio, I'd welcome the conversation.